Researchers have identified a protein that helps prevent excessive scar scar in wound healing. Protein, called fibromodulin (FMOD), forms a complex of molecules with 1β interleucin that prevents myofibroblasts from forming an excessive scar tissue.
The findings could lead to a new way of reducing or preventing excessive scars, which could benefit patients who recover from surgery, injuries or burns. The study is published in Nature communications.
In previous studies, the researchers described the critical role of FMOD that had to enable fetal repair without scars, as well as to prevent repair of excessive scar adult type. For this new study, the researchers investigated the effects of PMOD on myofibroblasts, a key cell in healing and scars formation. Myofibroblasts should do so after a heals wound, but they can form the continuous formation fabric much later, which leads to excessive scars. Fibromodulin -based complex promotes the death of myofibroblasts.
“Dr. Eric Kang Ting and I have been studying how to reduce skin scars during the last two decades in UCLA,” says Chia Soo, MD, Surgery professor and research vice president of the UCLA and Reconstructive Surgery Division of UCLA, in a liberation. “This publication explores the crucial role of naturally occurring fibromodulin in regulating a Key Scar-Forming Cell, The Myofibroblast. This, Combined with Our Team’s Fda-Approved Clinical Study Led by Dr Zhong Zheng intengg Fibromodulid a fibromodulid a fibromodulid to fibromodulid a fibromodulid a fibromodulid a fibromodulid a fibromodulid a fibromodulid a fibromodulid a fibromodulid a fibromodulid a fibromodulid a fibromodulida to fibromodulida to fibromodulid Fibromodulid reduction, demonstrates a significant jump of fibromodulida with a potential fibromodulid jump.
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